well the overall lethality of each weapon is completely different.. broadheads cause death by hemoraging and guns by hydrostatic shock.. minus the destruction of vital organs.. i personally only notice a difference in the overall cleanlyness of the wounds.. a broadhead whether its 2 bladed or 3 leaves a very distinct and clean mark where as a bullet is gonna enter small and leave a big exit depending on the size of gun used and bullets...im my experience its very hard to mistake a gun shot for a bow shot...a muzzle loader wound will be similar to a rifles but with much more damage at P.O.I due to the shear size and weight of the projectile.. i used a 300 win mag on deer and the hole was no different than that of an 06 unless you connect with bone then its a different story. .but my .50 cal inline puts the same size hole in deer that my 270 does..