Well It seems to me that you have a dead deer by now. A bullet placed behind the shoulder with that load and range should have done the job - especially with a pass through.
You said it was planted pines and fairly open, so I'm picturing an area where a deer could not crawl under the lower branches of a tree and be concealed, right? I have found a deer that had done that once.
About the only thing you can do is keep looking, and try not to scuff the pine needles or leaves too much as you make those widening circles around where you last saw blood.
One thing to keep in mind is that a deer can abruptly change the direction of travel from one jump to the next, so it may not continue in a straight line.
I also would check more downhill, if there is a downhill there, as they often will naturally take the path of least resistance (down) if possible.
Good Luck!