Yes it can be done, i've done it several times. One of the tests to graduate from PSE school is to change one over from right to left. On a duel cam bow you need a new left riser and reverse the cams. One cam you need a new cam and riser. It's usually cost prohibitive though, the parts cost as much or more than just getting a lefty bow. Oops , almost forgot.... you have to switch limbs too from bottom to top on some models. Some models you can't switch from left to right.