I have one ML, so I would take it for both scenarios.
White UltraMag .504. with 90 gr T7 ff behind a Bullshop 460 gr conical.
Scope is a Bushnell 3-9X which shoots this load 2" high at 100 yds. and would be removed to use the factory open sights out to 75 yds.
Like SHulion, I would hope to be able to check the open sights before taking a shot at game, since I usually use it with the scope.