IMHO the 300 Win Mag would be the choice. It is a fine all round chambering. I find the 338 Win Mag a very "snotty" round. For what one gains over the 300 I don't believe the punishment is worth it. It's a round that kills on both ends of the rife. If you need more that what the 300 offers I'd rather move up to my 375 H&H which to me is morecomfortable to shoot than the 338. That being said the new 338 fed and rugers are interesting without the punishment of the 338win mag