looking on buffalo bores website i see a +p load advertised at 1325 fps with a 325 grain bullet. thats about the same velocity my nephew sends 300 grain sst's from his lyman buskstalker (about 1400 fps average through my chrony). it is a reduced load since hes still about young but he has taken 2 small bucks at under 50 yards and i witnessed both go down. so a +p load will kill and it can do it will IF the bullet is placed well. in general i think i am siding with vapodog, it will kill but its not anywhere near my first choice if theres a option.