You will get a million answers with that question. You need to narrow things down a bit. Do you want an inline or a traditional style gun? How much money do you plan to spend? Prices range from $100 up to whatever you want to spend. What are you planning to shoot at? Will it be a plinking gun or a hunting gun?

If you are new to the sport and want an entry-level inline gun for a low price, the CVA Wolf is a nice rifle without any extra bling. Keep tacking on the $ and you can move up through the ranks.

I've shot both calibers and killed deer with both. I haven't shot any inline 45's though, only sidehammers. If you're shooting deer-sized game, a .45 will kill the biggest buck you find. If you're after elk or moose, I'd imagine you would be better off with a .50. Some people claim .45 accessories, bullets, etc are hard to find, but that's if the only place you shop is Walmart. The .50 seems to be most peoples' choice.

rw