Just like the diaper - Depends.

Do you want a sidelock or in-line? Do you intend to hunt with it, plink, serious target shooting, some combination? Are you more inclined to find one good effective load and stick with that, or do you like to tinker around with a lot of different stuff? If it's primarily for hunting (whitetails only?), what is the average and maximum range you expect to shoot?

See, it's a diaper - and a dirty one at that.