Yes, they don't always give the perfect shot, but rather than alerting them and risking that they jump instantly, I have taken a few neck shots.

Last buck I shot was a nice 9 point. The wind was coming from the north, and I was moving into the wind. The end of a small cornfield was to my right about 75 yards away and I stopped to wait a while. After maybe 5 minutes I saw a doe come out of the standing corn, so I waited hoping a buck was following. She worked her way downwind and eventually winded me I assume, because she came back after a few more minutes looking like something had bothered her. Waited 10-15 more minutes and proceeded north. In this piece of woods there is a 3 trunked oak that I like to stand next to. The paln was to get to that tree eventually, and wait 20 minutes or so before continuing. The land is basically flat, but there is a slight rise there, and it make a good vantage point. I stopped when I knew I was about 50-60 yards from that oak to look for its exact location. As I saw the tree, I noticed something out of place near the base. Then it came together, there was a deer bedded right next to that tree. Then I saw one side of the rack and knew he was a shooter in my book. The deer was looking my way, but had not seen me. Very slowly I raised my scoped shotgun, found the deer in the scope. No good angle to the vitals, but there was his white throat patch. At this point I think the deer saw me, or at least knew something was up as he got wide-eyed. The cross-hairs were centered on his neck, so I let her rip. Lights out.