The problem with these big bores is if you need to shoot more then once the recoil can slow you down on the follow up shot. I deep penetrating 240gr. bullet from a 44 mag would be my choice it has plenty of power and is still managable.

B&B mentioned the bear killed with the 45 auto in Alaska a few months ago. The article I read the guy shot the bear 9 times and it ran off and die 100 yards away. I want something with a little better stopping power then that but still managable.