Not so much the calibers that bother me, it's the bullet construction that seems to jump out at me.
Ive heard so many stories of faliures over the years, from various calibers, then find out later in the conversation, the hunter was using something like a 180gr A-frame style bullet in a 300mag.
It probably just zipped right through the 90lb deer without veering or expanding, making a little hole. A 150gr cheapo Core-lokt would've dropped the deer.
Thats a rough rendetion of just one actual story, but you get the idea.
In that case, the 300Mag was compared to, as being less effective than a 7mag.
Heard many others using too light of a bullet, or HP's or Btips,......
It doesn't take much to kill a deer, but it does take a balance of everything involved.