For dropping them on the spot the 250 gr Gold Dot or curl as they changed the name has consistently done it the Nosler 260 would be next best after that the Barns. It has been my experience that the heavier bullets kill deer just fine but are actually designed for heavier game and open slower and the deer runs before dieing.
It is also my experience that placing the shot a couple inches above the heart so it destroys the large arteries above the heart and both lungs makes a big difference.