I have a 300 WM in a Remington Sendero. It's a heavy rifle and helps with the recoil a little. With 180gr loads it's not that bad to shoot. It gets interesting when loaded with 200gr or 220gr bullets. I am currently hunting with a 280AI because I wanted a lighter rifle for packing around. My 300 tipped the scales at 13 pounds loaded, scoped, and sling. Kind of heavy to be lugging up and down the Mountains at elevation. The funny thing is though my 280AI feels like it kicks just as hard as my 300WM because it's only about 7.5 pounds.
In the end you are the one who has to spend the money and you're the one who will either be happy or not.