To my great shame, I once had to make a shot at 150 yds.

I normally am able to hunt within 50 yds or so of any animal I want to shoot. This particular bear was crossing a beaver dam and I thought it was wounded by another hunter, so I took the shot to put it away. As it turns out it was wounded, and probably would have expired after a long run in swampy country - we may never have recovered it.