Consistency on the chrono. Followed by consistency on the target. Those are the only two things that really matter (if you aren't exceeding safe pressure). You might get the first without the second, if the round doesn't work for the specific rifle...in which case, change the load for the rifle.
The charts you will find will all vary for expected velocity for the powder weight. There are times when the best powder for a specific chambering won't work with a specific rifle (such as a shortened barrel, strange twist, or such).
I'd just say, don't push things too much for velocity. Look at the charts, try to match rounds to the rifle, and just find a comfortable ground.