If you' re left handed, you could be canting your bow to the right. That would cause you to hit right.

Other than that, you may be starting out with a different grip, and torqueing the bow. After shooting a few times, the bow then slides into the proper spot on your hand where you have your bow set up for. I solved this problem by wearing a jersey glove for all my shooting. 3-D, Indoor, hunting, everything. I always have that plain old brown jersey glove on my hand.