That's exactly the question I've been pondering Cayugad. Take a look at the chart below with ballistics for the 200 grain XTP, 180 grain Gold Dot, and 210 grain Gold Dot, all launched at 1750 fps.

That 180 grainer looks pretty anemic. But then I consider this: The 10mm Auto is considered a fine handgun hunting round for whitetails, falling about midway between the .357 Magnum and .41 Magnum in power and easily capable of clean kills at 50 yards. A hot load with a 180 grain bullet in the 10mm Auto has a muzzle velocity just under 1300 fps, and a 50 yard velocity around 1150 fps. My 85 grain load is beating that velocity all the way out to 150 yards. I think that, as always, shot placement is key.