A .223 uses about 25% less powder than a .22-250 to push a 50 grain bullet. The .22-250 (max app. 3,800 fps) runs about 400 fps faster than the .223 (max app 3,400 fps), which means that a .223 has about 1.5 inches more drop at 300 yards (if the rifle is sighted in at 200 yards), and about 4" more drop at 400 yards. The .223 does not heat barrels up as much as a .22-250, so .223 barrels last quite a bit longer. The .22-250 is better for longer ranges, but at 300 yards there is very little difference between the two.