Heck, you can kill them with a .22 with proper shot placement but I wouldn't be the one who tried it. The thing I've found with pepper spray is you have to get TOOOOO close to whatever you shoot it at and, as said earlier, pay attention to the wind! Try a .460 Smith & Wesson. It'll shoot .454s and with the .460 S&W 200 gr Hornady it's point of aim at 200 Yds, so you can use it for deer too, ........ or cars or semis .......