As already mentioned, the 100 yard shots are not the smartest thing to do with the cartridges you mentioned. If you intend to shoot at that range I hope you are planning on mounting a scope too. Anyways, back on topic. I enjoy my .41 magnum for deer hunting. It has open sights but has a little ghost ring rear sight that fits into the factory rear sight. This is nice for the type of hunting I do with it where I don't really shoot over 40 yards or so. I do not handload which makes it hard to get good .41 magnum ammo. Luckily Federal loads the 180 grain Barnes XPB round. The 44 magnum will definitely be more powerful but also recoil more, and I deem it unnecessary for my style of handgun hunting for deer. I own several .45 long colts and they are also quite capable deer guns too, especially so if you handload and use a modern gun. Someone already mentioned a .454 casull for you too. If you really want to shoot 100 yards, I would recommend this cartridge. It has been around a while and is not going anywhere and like mentioned, you can shoot .45 long colt ammo through it too.