falcon
I hunted with a PRB for many years before I built my first inline and it was a 40 caliber and built about 6 years before inlines and sabots were sold commercially.
There are no big secrets about it just a lot thats not commonly know by the last few generations. I used to take deer with a 45 PRB and 55 gr of black powder bullet placement was a bit different and more exact and we did not shoot over about 70 yds with a 45. I built many guns and finally decided that I like the 54 caliber with a 35 inch barrel and 120 or 130 gr powder with a 1-70 or a 1-80 twist and though I love to play with my inlines I have not seen any thing more effective than my 54 caliber Hawken which I built off a copy of the plans drawn off the Hawken in the ST Louis museum. It will drop a deer on the spot every time with the bullet placed just over the top of the heart. the 45 Hawken and the 45 under hammer [which I still have have] taken a lot of deer but I had to track most of them for 80 yds or so. Lee