You are not going to believe this, but 100 grains of powder is more than enough powder, especially for deer. I shot my 600 lb cow elk in 2009 with 90 grains of Goex 2f and a 385 grain Hornday Great Plains. That was about a 100 yard shot, and I found the bullet on the off side right under the hide. It weighed 375 grains recovered. In 2005 I shot one with 80 grains and a 370 grain T/C. That was a 450 lb cow. I did not recover that bullet, it hit the spine and broke up.
Take that for what it's worth.
Marcial