100 grains of powder is "enough". Your gun may prefer less or more with a given bullet for best accuracy.

I shoot 100 gr of loose pyrodex and 350 gr Hornady FPBs in my in-line. This is a 125-150 yd load for deer. I keep saying I'll try BH209, but I have to burn through my pyrodex first. At my current rate of less than 10 shots per year, it will take a while.