The guy who farms my hayground down in SD, has bigger rifles but does all of his deer hunting with his 22-250. He has a 243 and a 6.5x55 but when opening day comes around he is packing his 22-250. I was never very happy with any of my 243' s for deer. I had a 6mm Remington which would not shoot spire points in the heavier bullets so I shot 100 grain Hornady round nose bullet in it they worked better for me.