I am 3 for 3 with 250 SW's out of an omega with 100 grains of 777. All shots under 75 yards and all 3 complete pass thrus, including breaking bone. One ran 15 yards and 2 ran 25 yards. The only rub for me is no blood trail (thankfully- none went far). Sounds like shot placement was the issue rather than bullet choice on the OP's description.