What's best is a matter of perspective, and very subjective depending on whom you ask. Having said that, I used to swear by Muzzy 3 blade 100gr.; however, I'm hooked on the 100gr. Grim Reaper's.
The one's I use have the same trocar--bone crushing tip--as the Muzzy, but it also includes three small razors in the tip to aid penetration. I also like the simplicity of the Grim Reaper and the fact that they can be shot opened or closed for those places that do not allow mechanicals. They also fly as true as bullet points, which is a definite plus.
I shot three deer with them this year. One, a doe, who dropped within a few feet from my stand, and two bucks that made it 30 and 40 yards with blood trails that I could easily track in the dark.
Not saying they're the best, because I haven't tried everything, but I couldn't be more happy with the performance of the Grim Reapers!