Whitetail deer really are not very " big" big game. With a .270 Winchester using any bullet weight from 130 to 150 grain in a " Premium" bullet you will shoot completely through a Whitetail from any angle. When using bullets from 130 to 150 grain with " standard" bullets you will do the same thing " most" of the time. In a lifetime of whitetail hunting you will probably NOT completely shoot through your whitetails with that .270 less than a hand full of times total.

So find a load your rifle likes....and stick to it. (If you find yourself hunting heavy and or thicker skinned game then look particularly to the premium bullets or the heavier weight standard bullets.) When we lived in Alaska my wife frequently carried a .270 Winchester loaded with 160 grain Nosler Partitions or a .358 Winchester loaded with 250 grain Speer HotCor Bullets.