No the 25-06 is not a weird caliber. I was a 243 guy for years until I tried the 25-06. Wow...what a difference. I own a Remington 700 DM that I bought a McMillian stock for.
I was telling my neighbor that I killed 5 deer now with the 25-06 and everyone has been a bang-flop. He was in need of a rifle this season in Wisconsin so I lent him my rifle. Two deer...two bang flops. I shot many deer with the 35 Whelen and the 30-06 and neither one dropped them as fast as the 25.
I suspect it has to do with the velocity of the 100 grain bullet (3450 fps) and the all copper bullet....alway two holes. As you can see from the coyote picture I posted earlier it doesn't make that big a hole on a coyote. Tika also makes a wonderful little 25-06.