last year I took 2 deer at long distance. One was 234 yards. and 1 at 223 yards. At that time I was only shooting a 100 gr triple 7 and a 250 gr shockwave. The first deer went 20 yards and piled up. The bullet was lodged in the hide on the opposite side, so no exit wound. With the same load i took a deer at 223 yards. This deer also went less than 20 yards. the bullet was a complete pass through and killed a button buck standing behind her. ( 2 deer with 1 shot). This year I upped my charge to 130 gr triple 7 simply because I was using a new Knight and it prefers the higher charge. My longest shot this year so far is 130 yards. The exit wound was was about the size of 3 fingers and the deer dropped on the spot. There was a fist size chunk of lung laying beside it and 1/3 of the heart missing. I think 100 grains is sufficient for out to 250 yards if the shot placement is good. With a 130 grains I feel confident that a well placed shot will easily take out any deer that is in the 250 yard range with energy to spare.. I am using barnes TMZ and T-EZ or shockwave bullets this year depending on the gun. I hunt mostly mulies in the open plains . When I do hunt whitetail then my shots are usually less than a 100 yards. During muzzleloader season all my shots are usually a 100 yards or less because we are not allowed scopes. I only hunt with a scoped muzzleloader during rifle season. If you are consistent at 200 yards then I wouldn't be afraid to take a shot at that distance with a 100 gr of powder. I use the Omega scope and with a 100 gr I use the 250 reticle at 200 yards and hold about 2" high. That's where the Triumph shoots anyway. With the Knight and a 130 gr. I can shoot 200 yards with the 225 reticle dead on. That's my 2 cents based on the last 2 seasons.