I carry several different combos.
Sometimes a rife and a handgun, sometimes two handguns(like a scoped super 14 contender, and 629 44mag with iron sights).
I especially like having a handgun for close quarter/right side shots, that are almost impossible with a rifle.
Also, I have taken a deer through my ladder, when climbing down from the stand, with my rifle on the ground.
When Ive shot one, I'll put my rifle in the truck, and go back with a handgun only.
A lot easier towing a carcass without a rifle, plus, you might get a bonus shot at something.