I loaded some 220 gr 30-06's for a friend who went to Africa with me. He used them on plains game and they worked (I took 180 gr Barnes for a .300 Win Mag). If you've ever been in the service and used a 60mm mortar, they've got similar ballistics. 220 grainers are really too big for hunting anything in the lower 48 and I agree with a couple of prior posts, a 150 or 180 gr is fine for North American game and if you're punching paper the Palma Match bullets are primo.