Though they do seem to be accurate, my experiences with GameKings has been similar. I've not lost an animal, but I became accustomed to the 165 BTSPs in a mildly loaded .30-06 shedding jackets and nearly 60% of their original weight. They performed even worse in a .243.
Those results always seemed to amplify when hitting a solid mass of bone and tissue such as the shoulder. Tremendous near-side tissue damage and waste, but little penetration. Thus, I'm also a fan of the heart/lung shot over shoulder or neck.