I think the 30 cal 150 is a more frangible bullet and was built with the 308 and 30-06 in mind. If that is still the case, and 300 Wby/300 RUM velocities it would all but come apart. However, I haven't even considered a NBT for a lot of years so my info could be outdated.

The 338 Winny pushing a 225 Accubond at 2800 fps MV is amazing. I shot a hog in Texas with this combo, and it hit like the Hammer of Thor. I have never seen a hog go down so hard and so fast. It was a shoulder shot, placed a little higher than it should have been.

The most destructive bullet I have ever fired was a 165 grain Swift Scirocco out of a 300 Winny with an MV of 3150 fps. I shot a small Texas whitetail at about 100 yds, and hit it behind the shoulder. The entrance hole was nickle sized, and the exit was a 4" x 6" hole with internal organs pushed though broken ribs. Based on that, perhaps a bullet that expands a lot, impacts at high velocity, but still holds together may actually cause the most damage.