Back in the late 60s and early 70s I used a 22-250 for damage permit hunting, at that time we had a local law prohibiting centerfires over .22 caliber...I killed 50-60 deer with that gun and 55gr Remington bullets...When I started this practice I wasn't old enough to drive and my dad would drop me off on one of the farms and pick me up after dark...
Funny, those deer didn't care that I was only 13-14 years old....Those hit in the lungs ran 75-100 yards and keeled over, those hit at the base of the neck dropped right there...
Fast forward about 30 years...My younger brother picked up a used 22-250 on a trade, had me sight it in with 60gr Nosler Partitions...
My niece has killed 14 deer with this gun over the past 5-6 years...
Dang deer didn't notice that she was 14 when she started...Only 2 ever took another step and all had nice exit holes...