I shoot muzzies, 3 blade and 125 grains with a heavy arrow and no complaints. I keep my bow down to about 52 pounds, just for the ability to pull it back and wait when the deer pulls crap like stopping behind a tree, etc. (you know the drill) I've thought about trying out the rage just to see how it does, but then I would have to crank my bow up to 65 lbs or something like that just to be sure it penetrated enough. So that alone has stopped me because I don't have time to practice with the bow at that poundage. Plus I'm not 6'4 and 250 lbs... If you go with mechanicals, make sure your bow is putting out enough force to do it. I don't know what pounds minimum, but I would bet 60 at least. My arrows are slow and heavy, and I'm limited with my distance, but they are quiet and hit hard.
Just my rambling, but remember the most important thing is to hit the vitals whatever you use.