Can you put 150 gr. of powder in your gun. I'd check the owners manual but I would guess that the answer is yes. The thing is though, and most people in this room will tell you that unless you just need to up your self esteem, there really isn't that much of an advantage to going witha 150 gr. charge. I'd stick with the charge ya got.

On the topic of range, I would play out senario shots for what my average, shortage, and longest makeable shots are gonna be. I have one mL that I use for deep cover and I've got it so that at 50 yds its 1" high. My other ML is 2" at 100 and then does pretty good out to 150yd. Truth be told though, I've never taken a deer with a ML past 100 yds. My suggestion is practice up and try different distances.