All of the calibers you want to know about have severe recoil. There is no way around that. Get the most comfortable grips you can and it is what it is. For practice get a good shooting glove. I have some big paws and I use a glove when shooting the 500.

If you are not going to go with a 500 then my second pick would be the .460.

With stout loads a 460 will push about 2500 lbs of energy and a 500 will go 3000+.