Well...When I was testing different brand loadings for my .243 I found that deer shot with the 100gr Federal Premium Sierra GameKing SPBT would drop within 25-30 yards with a lung shot...
But...With Remington Premium 100gr SPBT CoreLokts the deer hit in the lungs ran 100-125 yards...Fortunately Remington doesn't make this bullet anymore and if I was new to the .243 I would have gotten rid of it based on that bullet's performance...This is also a case of a "Premium" bullet giving poorer performance than the plain jane CoreLokts...
The Remington's were too hard, the always gave and exit and small exit wound...The Sierras usually exited on lung shots and gave massive internal damage...