Mike - If your 45 is shooting these 200 gr bullets good with 70 gr of powder that's great . That is a good starting point. My suggestion is to stick with the loose powder and forget the pellets. Try bumping up to 80 grs and see how your group is. If it as good or better that would be great. IMO, 80 gr of loose powder pushing a 200 gr (I assume it is a 40 cal bullet with a 45 cal sabot) bullet will be fine for any whitetail or hog out to 100 yards. I shot my biggest buck yet with this exact combo.