It' s all based on the ammo you choose and the ballistics for that particular load. Here' s two examples for Remington loads, but you want to look up the ballistics tables for the specific bullet you' re choosing.

120 gr HP
Short-range trajectory: 100 yd .6 high; 150 yd 0; 200 yd -1.9; 250 yd -5.3
Long-range trajectory: 100 yd +1.4; 200 yd 0; 250 yd -2.9

140 gr SP
SRT: 100 yd +.7; 150 yd 0; 200 yd -2.1; 250 yd -5.7
LRT: 100 yd +1.6; 200 yd 0; 250 -3.1

Basically, you should zero to 200, and you don' t have to concern yourself with 250.