.280 for all animals including large black bears. I think the 25-06 would be very fun for the coyotes. .280 rem is my favorite and have proven it deadly here on southern whitetails and on Canadian whitetails. Recently on a 6 1/2 foot Alaskan black bear. So far the bear was the only critter to take a step after impact, he only took 4 or 5 steps.