With regard to recoil... You must convince yourself.... There is no spoon.... Squeeze and follow through.
Unless you nuzzle your eyeball right up to that scope that thing isn't going to hurt you...
First rule of Design of Experiment... Change only one variable at a time. Thus, same ammunition to sight in with, hunt with, etc. If this means shooting various ammunition in order to find which one groups the best then so be it. Once that is established adjust POI to that ammunition... practice with that ammunition and hunt with that ammunition.