I hate to rely completely on one guy' s website, but ever since it was brought up here, I' ve used it when I need a little light reading about guns.
http://www.chuckhawks.com/25-06Rem.htm
http://www.chuckhawks.com/7mm-08.htm
I' d say, basically, that the .25-06 is the smallest gun I would use on really big whitetails, as opposed to the .243 for smaller (Southern) deer. With the 7mm-08 I wouldn' t have qualms shooting any deer that stepped out. There is no animal I would definitely shoot with the 7-08 and not the .25-06, but there is a little more ' umph.' On the other hand, the ' 06 is a better varmint gun.