I would recommend trying as many different bullets and weight as you can afford. I know that sounds like a lot of work, but isn't that the best part! I handload exclusively. I have an NEF 243, and an Encore in 243, neither will shoot the same bullet as well as the other. But once I dialed in what either one preferred, they are tackdrivers. You just need to be aware of different twist rates making some guns shoot varmit bullets better than big game bullets. IE, Nosler makes a varmit ballistic tip as well as a big game ballistic tip. Just something to be aware of when reloading.