I shoot the Optima Elite, and did very little testing before finding a recipe that left me extremely pleased. My mixture:
Winchester 209 primers
150 gr. triple seven (3 50 grain pellets)
295 gr powerbelt copper series bullets

I am shooting with open sights, and can put three shots inside just about an inch at 75 yards. I don't figure on taking shots at any distances much farther than that where I will be hunting, but feel that I would be comfortable if the situation arose.