High shoulder shot or at the base of the neck. Fairly big target and a sure stopper if you are close enough to make a 100% shot. My last elk was at 50 yards in with a bunch of cows which were covering his body and I had to make a neck shot. They knew I was there and were about to bolt so I took the shot and he dropped dead on the spot. Nothing wrong with a broadside boiler room shot either especially at a distance.