What is the reason for a DRT shot? Is it to stop the animal from going over a property line, terrain, etc? Or is it instant gratification, poor woodsmen skills or lazy? Sorry thinking out loud again...inside voice..inside voice!!
CNS shots are your best bet (this is spinal & head). However these shots offer the smaller target zone, so if one is attempting them they must be proficent with their firearm in all facets (includes: knowing the yardage, target/crosshair placement, rest, etc). The high shoulder shot is a CNS shot, yes it busts both shoulders but if you place it correctly it will also gets the spinal cord. The target is orange sized on a mature deer sized animal. This shot offers the most margin of error.
Personally I like the 1/4 away shot, be it bow or gun. This leaves the vitals unobstructed and exits through the opposite shoulder/leg. Not to mention it gives you an excellent visual target by aiming for the opposite leg. Bloodtrails are excellent hear IME as the you usually obtain a pass thru with a rifle, though the game rarily goes far with such a hit & both lungs deflated. I can say the same about a broadside behind the shoulder as well though. I have needed the high shoulder shot due to terrain and it does work when you do your part, though if I don't have a reason for limiting the scamper I'll chose to pull it back and down 100 out of 100 times.