I had bought a box of 50 of the 300gr noslers about 4 months ago. I have heard good things about the Barnes but wanted to give the Noslers one more chance with the different sabot. I actually think the best my gun ever shot was the combo that Tony Knight told me to use; 110 gr of pyrodex and a speer 260 gr jhp. This was the only time in my hunting experiences that I saw deer hit broadside and literally flop over like they had been hit by lightning.But the grass is always greener theory applies and I keep looking for the perfect combo that may beat the speers.