DeerandbearhoG makes a very valid point regarding cartridge availability. For years I elk hunted with my 280. After a "bad day" at the zero check range in Colorado, I found myself needing/wanting cartridges. NONE anywhere. As it turned out, I didn't "need" any and killed a bull the next day.
I now hunt with a 30-06 and the 280 goes along as "spare". The point is, ALL stores stock 30-06, 270, and 7mm Rem Mag.