I kill deer with a 243 with 110gr bulletts and never had a problem with 1 shot kills. It was one of my late fathers favorite rifles. Out of respect for him I always try to shoot at least 1 deer with it every year.My main rifle is a 7mag weatherby I use 175gr in that one and my wife shoots dads old 257 roberts with 115gr and my girl uses a 270 with 130gr and has never had any problems. I would try both and see which one seems to shoot the best in your set up. Good luk deerman